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Updated: Feb 1, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
Designing Multivalent Ligands to Control Biological Interactions: From Vaccines and Cellular Effectors to Targeted
Ammar Arsiwala1, Ana Castro1, Steven Frey1
1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia-, 30332, USA.
Abstract:
Multivalent interactions in which multiple ligands on one object bind to multiple receptors on another are commonly found in natural biological systems. In addition, these interactions can lead to increased strength and selectivity when compared to the corresponding monovalent interaction. These attributes have also guided the design of synthetic multivalent ligands to control biological interactions. This review will highlight the recent literature describing the use of multivalent ligand display in the design of vaccines, immunomodulators, cell signaling effectors, and vehicles for targeted drug delivery.
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