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Skin adverse events in recently approved targeted therapies in solid malignancies

Maya Habre1, Antoine Salloum1, Samer Bassilios Habre2

  • 1Department of Dermatology, Saint George Hospital, Faculty of Medicine, University of Balamand, Beirut, Lebanon.

Future Oncology (London, England)
|December 8, 2018
PubMed

Insights

Targeted anticancer therapies offer precise cancer cell attack with fewer side effects than chemotherapy. This review details common skin reactions like rashes and xerosis from these advanced treatments.

Area of Science:

  • Oncology
  • Dermatology

Background:

  • Targeted anticancer therapies represent a significant advancement in cancer treatment.
  • These therapies selectively inhibit molecules crucial for tumor growth and progression.
  • They are broadly classified into monoclonal antibodies and small molecule inhibitors.

Purpose of the Study:

  • To provide a comprehensive review of dermatologic adverse reactions associated with targeted anticancer therapies.
  • To highlight specific skin toxicities linked to recently approved targeted agents.

Main Methods:

  • Literature review of studies on targeted therapies and their dermatologic side effects.
  • Analysis of reported adverse events, focusing on skin manifestations.
  • Categorization of side effects based on therapy type and mechanism of action.

Main Results:

  • Dermatologic adverse reactions differ from those of traditional cytotoxic chemotherapy.
  • Common skin toxicities include rashes, xerosis (dry skin), hand-foot-skin reactions, and mucositis.
  • Recently approved targeted therapies present unique dermatologic profiles requiring specific management.

Conclusions:

  • Understanding the spectrum of dermatologic side effects is crucial for managing patients on targeted therapies.
  • Early recognition and management of skin toxicities can improve patient compliance and outcomes.
  • Further research is needed to elucidate mechanisms and optimize treatment for these adverse events.
Keywords:
dermatologicmonoclonal antibodiesside effectstargeted therapiestyrosine kinase inhibitors

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