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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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Anisotropic conductivity tensor by analyzing diffusion tensor for electrical brain stimulation (EBS).

Mun Bae Lee1, Yeon Hyang Kim2, Hyung Joong Kim3

  • 1Department of Mathematics, Konkuk University, Seoul, 05029, Republic of Korea.

Physics in Medicine and Biology
|December 8, 2018
PubMed
Summary
This summary is machine-generated.

We developed a new method to visualize electrical properties in the brain during electrical brain stimulation (EBS). This technique uses magnetic flux density and diffusion tensor imaging to map conductivity, aiding neurological disorder treatments.

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Area of Science:

  • Neuroscience
  • Biophysics
  • Medical Imaging

Background:

  • Electrical brain stimulation (EBS) is a key treatment for neurological disorders.
  • Measuring electric current distribution within brain tissue during EBS is challenging.
  • Cellular asymmetry causes uneven conductivity during low-frequency EBS.

Purpose of the Study:

  • To propose a novel method for electrical property imaging during EBS.
  • To reconstruct the anisotropic conductivity tensor using magnetic flux density and DTI.
  • To determine ion concentration in the extracellular space.

Main Methods:

  • Applying low-frequency external EBS.
  • Measuring one component of magnetic flux density.
  • Utilizing diffusion tensor imaging (DTI) data.
  • Decomposing the conductivity tensor into ion concentration and mobility.
  • Reconstructing the apparent anisotropic conductivity tensor.

Main Results:

  • Successfully reconstructed the apparent anisotropic conductivity tensor using EBS and DTI.
  • Recovered an orthotropic conductivity tensor reflecting extracellular space (ECS) effects.
  • Determined a scale factor related to ECS ion concentration.
  • Validated the method in animal experiments, visualizing brain electrical properties during EBS.

Conclusions:

  • The proposed method enables direct reconstruction of apparent anisotropic conductivity tensor imaging during EBS.
  • This technique visualizes electrical properties, offering insights into brain tissue responses to EBS.
  • The method aids in understanding unknown effects of EBS on brain tissue.