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Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
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Micro-channel sieve electrode for concurrent bidirectional peripheral nerve interface. Part B: stimulation.

Robert A Coker1, Erik R Zellmer1, Daniel W Moran1

  • 1Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, United States of America.

Journal of Neural Engineering
|December 8, 2018
PubMed
Summary
This summary is machine-generated.

Micro-channel sieve electrodes significantly reduce stimulation artifacts in peripheral nerve interfaces (PNIs) compared to thin-film transverse intrafascicular multichannel electrodes (tfTIMEs). This advancement is crucial for simultaneous recording and stimulation in advanced prosthetic limbs, improving signal quality for amputees.

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Haptic feedback is essential for prosthetic limb control, requiring effective peripheral nerve interfaces (PNIs).
  • Existing PNIs struggle with simultaneous recording and stimulation due to large stimulation artifacts obscuring neural signals.
  • Thin-film transverse intrafascicular multichannel electrodes (tfTIMEs) and micro-channel sieve electrodes are candidates for bidirectional PNIs.

Purpose of the Study:

  • To computationally model and compare stimulation artifacts between tfTIMEs and micro-channel sieve electrodes.
  • To evaluate the impact of micro-channel geometry and stimulation configurations on artifact levels.
  • To assess the potential for micro-channel sieves in achieving high signal-to-artifact ratios for bidirectional PNIs.

Main Methods:

  • Finite element modeling was used to simulate electric fields during peripheral nerve stimulation.
  • Axon models simulated electrophysiological responses to stimuli.
  • Stimulation artifacts were calculated for threshold stimulation currents across various electrode designs and configurations.

Main Results:

  • Micro-channel sieve electrodes produced lower stimulation artifacts at threshold currents compared to tfTIMEs.
  • Stimulation artifacts for tfTIMEs were 2-3 orders of magnitude larger than electro neurogram (ENG) levels.
  • Certain micro-channel configurations achieved artifacts 3-4 orders of magnitude smaller than ENG levels, with bipolar and tripolar configurations showing significant reductions.

Conclusions:

  • Micro-channel sieve electrodes offer a promising solution for reducing stimulation artifacts in bidirectional PNIs.
  • Optimized micro-channel designs and stimulation configurations can enable effective simultaneous recording and stimulation.
  • This technology can enhance sensory feedback and motor control for amputees using prosthetic limbs.