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Updated: Feb 1, 2026

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis
Published on: September 2, 2021
Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis
Foteini Christidi1, Efstratios Karavasilis2, Michail Rentzos1
1First Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Abstract:
Amyotrophic lateral sclerosis (ALS) is now universally recognized as a complex multisystem disorder with considerable extra-motor involvement. The neuropsychological manifestations of frontotemporal, parietal, and basal ganglia involvement in ALS have important implications for compliance with assistive devices, survival, participation in clinical trials, caregiver burden, and the management of individual care needs. Recent advances in neuroimaging have been instrumental in characterizing the biological substrate of heterogeneous cognitive and behavioral deficits in ALS. In this review we discuss the clinical and radiological aspects of cognitive and behavioral impairment in ALS focusing on the recognition, assessment, and monitoring of these symptoms.
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