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Intramyocardial Cell Delivery: Observations in Murine Hearts
Published on: January 24, 2014
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Cell surface engineering and application in cell delivery to heart diseases
Daniel Y Lee1, Byung-Hyun Cha1, Minjin Jung1
1Division of Cardio-Thoracic Surgery, Department of Surgery, University of Arizona College of Medicine, Room 4302D, 1501 N Campbell Ave, Tucson, Arizona 85724 USA.
Journal of Biological Engineering
|December 8, 2018
Summary
This review explores non-genetic cell surface modification techniques for advanced cell-based therapies. These methods offer versatile alternatives to genetic engineering for cancer immunotherapy and regenerative medicine.
Area of Science:
- Biomedical Engineering
- Cell Biology
- Immunotherapy
Background:
- Cell-based therapies are crucial in cancer immunotherapy, regenerative medicine, and tissue engineering.
- Cells are attractive for advanced therapies due to their secretory functions, differentiation, homing, and ex vivo expandability.
- Modifying cell functions is central to biomedical research for therapeutic applications.
Purpose of the Study:
- To review current non-genetic cell surface modification techniques.
- To discuss the limitations of genetic modification in cell engineering.
- To explore applications in cardiac remodeling and future prospects.
Main Methods:
- Chemical conjugations
- Polymeric encapsulation
- Hydrophobic insertion
- Enzymatic and metabolic addition
Main Results:
- Non-genetic methods offer alternatives to permanent genetic modifications.
- Various techniques allow for controlled cell surface engineering.
- These methods have potential applications in tissue repair and regeneration.
Conclusions:
- Non-genetic cell surface engineering provides flexible therapeutic strategies.
- Further research into these methods can advance regenerative medicine and immunotherapy.
- Cell surface engineering holds promise for cardiac remodeling and other applications.
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