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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Fetal microchimerism in mouse caerulein-induced pancreatitis model
Zahra Vojdani1, Jafar Bagheri1, Tahereh Talaei-Khozani1
1Laboratory for Stem Cell Research, Anatomy Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Iranian Journal of Basic Medical Sciences
|December 8, 2018
Summary
Pregnancy may protect against acute pancreatitis (AP) in mice. Fetal cells (microchimerism) were found in the pancreas, potentially aiding recovery from AP.
Area of Science:
- Reproductive Biology
- Immunology
- Gastroenterology
Background:
- Fetal microchimerism involves fetal cells persisting in the maternal body.
- Acute pancreatitis (AP) is an inflammatory condition of the pancreas.
Purpose of the Study:
- To investigate fetal microchimerism in the pancreas of mice with acute pancreatitis.
- To assess the impact of pregnancy on AP severity in a mouse model.
Main Methods:
- Established an acute pancreatitis model in mice using caerulein injection.
- Utilized EGFP+ transgenic mice to track fetal cells.
- Analyzed pancreatic tissue via histopathology, immunohistochemistry, and PCR.
Main Results:
- Fetal EGFP+ cells were detected in the pancreas of pregnant mice with AP.
- These cells differentiated into various pancreatic cell types.
- Mice with a history of pregnancy showed improved pancreatitis scores.
Conclusions:
- Pregnancy appears to exert a protective effect on acute pancreatitis in mice.
- Fetal microchimerism may play a role in the beneficial impact of pregnancy on AP.
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