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Related Experiment Video

Updated: Feb 1, 2026

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
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Tooth Repair and Regeneration.

Ana Angelova Volponi1, Lucia K Zaugg1,2, Vitor Neves1

  • 11Centre for Craniofacial and Regenerative Biology, Dental Institute, King's College London, London, UK.

Current Oral Health Reports
|December 8, 2018
PubMed
Summary

Regenerative dentistry offers biological repair alternatives to traditional dental treatments. Key advancements include enamel remineralization, dentin repair via Wnt signaling, and whole tooth engineering using odontogenic cells.

Keywords:
Bio-toothBiological repairDentinogenesisRegenerative dentistryReparative dentin

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Research

Background:

  • Current dental treatments predominantly rely on conservative methods and inorganic materials.
  • There is a growing need for innovative approaches to dental repair and restoration.

Purpose of the Study:

  • To explore and discuss recent achievements in regenerative dentistry.
  • To present biological repair as a viable alternative to conventional conservative dental approaches.

Main Methods:

  • Critical analysis of existing literature on tooth repair strategies.
  • Review of three primary approaches: enamel remineralization, dentin biological repair, and whole tooth engineering.

Main Results:

  • Enamel remineralization techniques are advancing.
  • Biological repair of dentin shows promise, particularly through understanding the Wnt signaling pathway.
  • Whole tooth engineering is progressing, with a focus on identifying suitable odontogenic cell sources.

Conclusions:

  • The Wnt signaling pathway is crucial for reparative dentin formation, offering a new translational approach for clinical dental treatments.
  • Future advancements in bio-tooth engineering depend on establishing viable and accessible odontogenic cell sources.