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Updated: Feb 1, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
Monozygotic Twins Suffering From Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report
Hui-Jun Tan1, Mei Deng1, Jian-Wu Qiu1
1Department of Pediatrics, The First Affiliated Hospital of Jinan University, Guangzhou, China.
NTCP deficiency, caused by SLC10A1 variants, can lead to transient cholestasis in infants and persistent hypercholanemia in children. Genetic analysis confirmed this in monozygotic twins with a pathogenic variant.
Area of Science:
- Hepatology
- Genetics
- Biochemistry
Background:
- Sodium taurocholate cotransporting polypeptide (NTCP), encoded by the SLC10A1 gene, is crucial for transporting conjugated bile acids into hepatocytes.
- Clinical manifestations of NTCP deficiency are not well-documented, despite extensive research on its function.
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