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Knowledge of the sample size is the first requirement to conduct random sampling or an experiment. The sample size is the total number of units, observations, or groups (in some cases) used to get the data to estimate a population parameter. As the name suggests, the sample size is that of the sample drawn from the population and differs from the population size.
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Multireader sample size program for diagnostic studies: demonstration and methodology.

Stephen L Hillis1,2, Kevin M Schartz2

  • 1University of Iowa, Departments of Radiology and Biostatistics, Iowa City, Iowa, United States.

Journal of Medical Imaging (Bellingham, Wash.)
|December 8, 2018
PubMed
Summary
This summary is machine-generated.

This software calculates sample sizes for diagnostic reader-performance studies. It aids researchers in determining the necessary sample size for detecting performance differences between imaging modalities.

Keywords:
Dorfman–Berbaum–MetzObuchowski–Rockettediagnostic radiologymultireader multicasereader performancesample size estimation

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Area of Science:

  • Medical Imaging
  • Biostatistics
  • Health Informatics

Background:

  • Reader performance studies are crucial for evaluating diagnostic accuracy.
  • Accurate sample size calculation is essential for the statistical power of these studies.
  • Existing methods for sample size computation can be complex.

Purpose of the Study:

  • To introduce a user-friendly software tool for sample size calculations in diagnostic reader-performance studies.
  • To implement established statistical methodologies for sample size determination.
  • To support researchers in designing robust diagnostic accuracy studies.

Main Methods:

  • The software implements sample size computations based on methods by Dorfman, Berbaum, Metz, Obuchowski, Rockette, and Hillis.
  • It focuses on calculating sample sizes for detecting differences in reader performance measures, such as the area under the receiver-operating-characteristic curve.
  • The program utilizes an intuitive interface for inputting study parameters.

Main Results:

  • The "Multireader sample size program for diagnostic studies" provides accurate sample size estimations.
  • It accommodates various study designs, inference procedures, and hypotheses.
  • The software is compatible with Windows, OS X, and Linux operating systems.

Conclusions:

  • This software simplifies the process of sample size calculation for diagnostic reader-performance studies.
  • It enhances the efficiency and accuracy of study design in medical imaging research.
  • The tool supports researchers in obtaining reliable results for reader performance evaluation.