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Published on: December 8, 2016
Stitching up broken DNA ends by FANCA
Anna Palovcak1, Wenjun Liu1, Fenghua Yuan1
1Department of Biochemistry & Molecular Biology, University of Miami Miller School of Medicine, Miami, USA.
Abstract:
RAD52 rejoins resected broken DNA ends by mediating single-strand annealing. Our recent work elucidates that FANCA, a Fanconi anemia protein, also directly repairs double-strand breaks (DSBs) by catalyzing annealing of single-stranded DNA. FANCA and RAD52 likely play complementary roles to each other to prevent deleterious consequences of DSBs. Abbreviations: DSBs: DNA double-strand breaks; ICL: interstrand crosslink; ssDNA: single-stranded DNA; HR: homologous recombination; SSA: single-strand annealing; MMEJ: microhomology-mediated end joining; NHEJ: non-homologous end joining; GFP: green fluorescence protein.
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