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Stroke Recovery in Rats after 24-Hour-Delayed Intramuscular Neurotrophin-3 Infusion.

Denise A Duricki1,2, Svetlana Drndarski3, Michel Bernanos4

  • 1Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.

Annals of Neurology
|December 8, 2018
PubMed
Summary
This summary is machine-generated.

Peripheral infusion of Neurotrophin-3 (NT3) protein improved sensorimotor function and neuroplasticity in rats after stroke. This finding supports NT3 as a potential therapy for stroke patients, with prior trials showing safety.

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stroke Research

Background:

  • Neurotrophin-3 (NT3) is crucial for locomotor circuit development and function.
  • Previous studies demonstrated gene therapy with NT3 improves sensorimotor recovery post-stroke.

Purpose of the Study:

  • To investigate if intramuscular infusion of NT3 protein can enhance sensorimotor recovery after stroke.
  • To assess the therapeutic potential of peripheral NT3 administration in a stroke model.

Main Methods:

  • Rats with ischemic stroke received NT3 protein or vehicle via intramuscular infusion 24 hours post-stroke.
  • Treatment was administered for 4 weeks using implanted catheters and minipumps.
  • Radiolabeled NT3 distribution and functional recovery were assessed.

Main Results:

  • NT3 crossed the blood-brain and blood-spinal cord barriers.
  • NT3 improved forelimb placement accuracy, arm use for support, and reversed sensory impairment.
  • NT3 induced neuroplasticity in spared corticospinal and serotonergic pathways without enhancing peri-infarct blood oxygenation.

Conclusions:

  • Delayed, peripheral NT3 infusion effectively improves sensorimotor function after ischemic stroke.
  • The established safety of peripheral NT3 administration in clinical trials supports its potential as a stroke therapy.