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Related Concept Videos

Chirality02:25

Chirality

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Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
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Chirality in Nature02:30

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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
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Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
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Related Experiment Video

Updated: Feb 1, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
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A DNA Origami-Based Chiral Plasmonic Sensing Device.

Yike Huang1, Minh-Kha Nguyen1,2, Ashwin Karthick Natarajan1

  • 1Department of Neuroscience and Biomedical Engineering , Aalto University School of Science , Aalto FI-00076 , Finland.

ACS Applied Materials & Interfaces
|December 12, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces a novel nanoscale biosensing device using DNA origami, chiral plasmonics, and aptamers for highly selective and sensitive target detection, even in complex fluids.

Keywords:
DNA origamiaptamersbiosensingchiral plasmonicsgold nanorods

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Area of Science:

  • Nanotechnology
  • Biotechnology
  • Materials Science

Background:

  • Accurate biosensing is vital for environmental monitoring, food safety, and diagnostics.
  • DNA origami nanostructures offer potential for creating custom sensing probes due to their spatial reconfigurability.

Purpose of the Study:

  • To develop a nanoscale biosensing device combining DNA origami, chiral plasmonic assemblies, and aptamers.
  • To achieve selective and sensitive detection of analytes in challenging sample matrices.

Main Methods:

  • Utilizing DNA origami nanofabrication for precise nanostructure assembly.
  • Integrating chiral plasmonic responses for unique optical detection signals.
  • Employing aptamers for high-affinity and selective target recognition.

Main Results:

  • Demonstrated a novel biosensing device with high accuracy and precision.
  • Achieved selective and sensitive detection of targets in strongly absorbing fluids.
  • The combined approach enhances detection capabilities in complex environments.

Conclusions:

  • The developed sensing scheme offers a versatile platform for detecting a wide range of analytes.
  • This technology can be tailored for specific diagnostic and monitoring applications.
  • The integration of DNA origami, plasmonics, and aptamers represents a significant advancement in biosensing.