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Updated: Feb 1, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
Published on: March 5, 2019
A DNA Origami-Based Chiral Plasmonic Sensing Device
Yike Huang1, Minh-Kha Nguyen1,2, Ashwin Karthick Natarajan1
1Department of Neuroscience and Biomedical Engineering , Aalto University School of Science , Aalto FI-00076 , Finland.
Abstract:
Accurate and reliable biosensing is crucial for environmental monitoring, food safety, and diagnostics. Spatially reconfigurable DNA origami nanostructures are excellent candidates for the generation of custom sensing probes. Here we present a nanoscale biosensing device that combines the accuracy and precision of the DNA origami nanofabrication technique, unique optical responses of chiral plasmonic assemblies, and high affinity and selectivity of aptamers. This combination enables selective and sensitive detection of targets even in strongly absorbing fluids. We expect that the presented sensing scheme can be adapted to a wide range of analytes and tailored to specific needs.
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