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Fluorous-Soluble Metal Chelate for Sensitive Fluorine-19 Magnetic Resonance Imaging Nanoemulsion Probes
Amin Haghighat Jahromi1, Chao Wang1, Stephen R Adams2
1Department of Radiology , University of California, San Diego , La Jolla , California 92093 , United States.
ACS Nano
|December 12, 2018
Summary
Researchers developed a new fluorine-19 MRI probe using a paramagnetic nanoemulsion. This probe enhances imaging sensitivity for detecting inflammation and cell therapies in vivo, improving cellular imaging capabilities.
Area of Science:
- Biomedical Imaging
- Materials Science
- Nanotechnology
Background:
- Fluorine-19 MRI (19F-MRI) offers background-free cellular imaging.
- Improving probe sensitivity is key to expanding 19F-MRI applications in detecting inflammation and cell therapies.
Purpose of the Study:
- To design and synthesize a novel, highly sensitive 19F-MRI probe.
- To accelerate the 19F longitudinal relaxation time (T1) for enhanced imaging sensitivity.
Main Methods:
- Synthesized and purified salicylidene-tris(aminomethyl)ethane (SALTAME) chelating agents.
- Formed stable metal chelates, focusing on Fe3+ for optimal T1 shortening.
- Created a paramagnetic nanoemulsion using Fe3+-SALTAME and perfluorooctyl bromide (PFOB).
- Assessed probe biocompatibility in macrophages and performed in vivo MRI in mice.
Main Results:
- Identified a SALTAME isomer with high perfluorocarbon (PFC) solubility.
- Fe3+-SALTAME chelate demonstrated superior T1 shortening at 3 and 9.4 T.
- Paramagnetic PFOB nanoemulsion showed potential for nearly 4-fold sensitivity enhancement.
- Successfully demonstrated in vivo detection of inflammatory macrophages in mice.
Conclusions:
- Paramagnetic PFC compounds, like the developed nanoemulsion, offer a promising platform for sensitive 19F-MRI probes.
- This approach can advance the detection of inflammation and cell therapies using 19F-MRI.
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