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Updated: Feb 1, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Fusaristatin C, a Cyclic Lipodepsipeptide from Pithomyces sp. RKDO 1698
Logan W MacIntyre, Douglas H Marchbank1, Hebelin Correa1
1Nautilus Biosciences Croda , Regis and Joan Duffy Research Centre , 550 University Avenue , Charlottetown , PE , Canada , C1A 4P3.
Abstract:
A new cyclic lipodepsipeptide, fusaristatin C (1), was obtained from the fungus Pithomyces sp. RKDO 1698, which was isolated from the Caribbean octocoral Eunicea fusca. The 2D structure of fusaristatin C was elucidated using NMR spectroscopy and mass spectrometry, while the absolute configuration of the sole chiral amino acid residue (l-serine) was determined using Marfey's method. 3-Hydroxy-2,11-dimethyltetradecanoic acid (HDMT) was cleaved from 1, and the absolute configuration at the C-3 position was determined using Mosher's ester analysis. Subsequent J-based configuration analysis of 1 allowed for assignment of the C-2 configuration. Fusaristatin C exhibited no antimicrobial activity or cytotoxicity.
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