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Updated: Feb 1, 2026

Preparation and Reactivity of Gasless Nanostructured Energetic Materials
Published on: April 2, 2015
Oxidative Cyclization Protocol for the Preparation of Energetic 3-Amino-5- R-1,2,4-oxadiazoles
Yongxing Tang1, Gregory H Imler2, Damon A Parrish2
1Department of Chemistry , University of Idaho , Moscow , Idaho 83844-2343 , United States.
Abstract:
An efficient method has been developed for the synthesis of energetic 3-amino-5- R-1,2,4-oxadiazoles via iodobenzene diacetate (IBD)-mediated oxidative cyclization in high yields at ambient temperature. Compound 1c has a graphite-like structure, which has seldom been reported in bicyclic compounds. The reaction of 3-amino-5- R-1,2,4-oxadiazole derivatives with hydrazine monohydrate in THF gives products that are a function of the substituent. Energetic performance calculations show detonation properties superior to TNT with concomitant lower impact and friction sensitivities.
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