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Reference value of Forced Oscillation Technique for healthy preschool children

Pinyapa Mukdjindapa1, Wiparat Manuyakorn1, Potjanee Kiewngam1

  • 1Division of Pediatrics Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University.

Asian Pacific Journal of Allergy and Immunology
|December 12, 2018
PubMed

Insights

Establishing reference values for Forced Oscillation Technique (FOT) parameters in healthy Thai preschool children is crucial. This study provides these vital FOT measures and reference curves for pediatric respiratory health assessment.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Biomedical Engineering

Background:

  • Reference values for Forced Oscillation Technique (FOT) parameters during inspiration and expiration in preschool children are currently unavailable.
  • Establishing these norms is essential for accurate diagnosis and monitoring of respiratory conditions in young children.

Purpose of the Study:

  • To determine and evaluate Forced Oscillation Technique (FOT) measures in a cohort of healthy Thai preschool children.
  • To establish normative reference values and curves for key FOT parameters in this population.

Main Methods:

  • A cohort of 390 healthy Thai preschool children aged 3-6 years was recruited, with strict exclusion criteria for respiratory and allergic conditions.
  • Forced Oscillation Technique (FOT) parameters, including resistance (Rrs), reactance (Xrs), frequency of resonance (Fres), and area of reactance (ALX), were measured.
  • Reference curves were generated using the lambda-mu-sigma (LMS) method based on height.

Main Results:

  • FOT was successfully performed in 96.9% of the enrolled children.
  • Normative data for whole breath (WB) resistance (R5, R20, R5-20) and reactance (X5, Fres, ALX) were established.
  • Significant differences were observed between sexes, and expiratory phase parameters were higher than inspiratory phase parameters. Height showed significant correlations with FOT parameters.

Conclusions:

  • This study successfully established reference curves for FOT parameters in healthy Thai preschool children.
  • The findings indicate that the FOT method is feasible and can be reliably performed in the majority of preschool-aged children.
  • These reference values are vital for the clinical assessment of pediatric respiratory diseases.
Abstract

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