Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse

Nicole Tay¹, Christine Macare¹, Yun Liu¹+40

• ¹The Centre for Population Neuroscience and Stratified Medicine and SGDP Centre, Institute of Psychiatry, King's College London (Tay, Macare, Ruggeri, Jia, Chu, Biondo, Ing, Quinlan, Desrivières, Barker, Schumann); the Department of Biochemistry and Molecular Biology, MOE Key Laboratory of Metabolism and Molecular Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China (Liu); the Institute of Science and Technology of Brain-Inspired Intelligence, Fudan University, Shanghai, China (Jia); the Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Ministry of Education, Shanghai, China (Jia); the School of Life Sciences and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Luo); Uppsala University, Uppsala, Sweden (Sarkysian, Bakalkin); the Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (Banaschewski, Hohmann); the Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Barker); the Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin (Bokde, Nees); University Medical Centre Hamburg-Eppendorf, Hamburg, Germany (Bromberg, Büchel); the Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (Flor, Nees); the Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany (Flor); the Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (Nees); the German Research Foundation, Bonn, Germany (Nees); NeuroSpin, Université Paris-Saclay, Gif-sur-Yvette, France (Frouin, Orfanos); the Departments of Psychiatry and Psychology, University of Vermont, Burlington (Garavan); Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom (Gowland); the Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin (Heinz, Walter); Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Berlin (Itterman); the Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," DIGITEO Labs, University Paris Sud-Paris Saclay, University Paris Descartes, Gif sur Yvette, France (Martinot); the Maison de Solenn, Cochin Hospital, Paris, France (Martinot); the Institut National de la Santé et de la Recherche Médicale, University Paris Sud-University Paris Saclay, DIGITEO Labs, Gif sur Yvette, France (Artiges); the Department of Psychiatry, Orsay Hospital, Orsay, France (Artiges); the Bloorview Research Institute, Holland Bloorview Kids Rehabilitation, Hospital and Departments of Psychology and Psychiatry, Bloorview Research Institute, University of Toronto, Toronto ( Paus); the Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany (Poustka); the Clinic for Child and Adolescent Psychiatry, Medical University of Vienna, Vienna (Poustka); the Department of Psychiatry and the Neuroimaging Center, Technische Universität Dresden, Dresden, Germany (Fröhner, Smolka); the School of Psychology and the Global Brain Health Institute, Trinity College Dublin, Dublin (Whelan); the Department of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany (Frieling, Bleich); the Department of Medical Sciences, Molecular Medicine and Science for Life laboratory, Uppsala University, Uppsala, Sweden (Syvänen); and the Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm (Rüegg, Ekström).