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Updated: Feb 1, 2026
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Isolation of Myoepithelial Cells from Adult Murine Lacrimal and Submandibular Glands
Published on: June 11, 2019
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Salivary myoepithelial cells: an addendum
Asterios Triantafyllou1,2, Lauge Hjorth Mikkelsen3,4, Douglas R Gnepp5
1a Department of Pathology, Liverpool Clinical Laboratories , Royal Liverpool University Hospital , Liverpool , UK.
Ultrastructural Pathology
|December 12, 2018
Summary
Salivary myoepithelial cells possess unique cilia involved in sensory reception and cell communication. This review examines their structure, function, and changes in disease, highlighting future research directions.
Area of Science:
- Cell Biology
- Histology
- Salivary Gland Biology
Background:
- Salivary myoepithelial cells have unique appendages and functions often overlooked.
- Previous reviews have not fully addressed the roles and characteristics of these cells.
Purpose of the Study:
- To comprehensively review the substructure, occurrence, detection, and functions of cilia on salivary myoepithelial cells.
- To discuss regressive changes, cell division, and implications for salivary neoplasia.
Main Methods:
- Review of existing literature.
- Analysis of substructure, occurrence, and detection methods including electron microscopy and advanced immunofluorescence microscopy.
- Examination of cellular processes like division and apoptosis.
Main Results:
- Cilia on myoepithelial cells play roles in sensory reception, evolutionary homology, and paracrine signaling.
- Regressive changes such as lipofuscin accumulation and cytoskeletal alterations occur.
- Myoepithelial cell division increases in chronic inflammation and experimental conditions.
Conclusions:
- Salivary myoepithelial cell cilia are crucial for various cellular functions.
- Understanding these cells' behavior is vital for studying salivary gland diseases and neoplasia.
- Further research is needed to clarify their roles and pathological alterations.
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