Related Experiment Video
Updated: Feb 1, 2026

Zebrafish Corneal Wound Healing: From Abrasion to Wound Closure Imaging Analysis
Published on: March 1, 2022
Wound Closure and Management
1Comprehensive Hernia Center, Digestive Disease and Surgical Institute , Cleveland Clinic, Cleveland, Ohio.
Background:
The management of incisions and decisions on closure techniques for surgical wounds are driven by expected incisional morbidity and the severity of the potential morbidity for the patient.
Methods:
This article reviews current literature on the potential strategies to be considered in closing the skin and fascia of incisions.
Results:
The review of the literature indicates that low-risk wounds for infection should be closed primarily with subcuticular suture, and adjunctive local measures should be avoided. Adjunctive measures of irrigation, topical antimicrobial agents, and negative pressure incisional therapy may have a role in high-risk wounds. Surgeons should strongly consider primary closure of contaminated wounds.
Conclusions:
The overall literature on adjuncts of wound irrigation, topical antimicrobials, and negative pressure wound therapy have potential to be of benefit but additional investigation is necessary since they do impact cost, patient experience, and antibiotic stewardship.
Related Concept Videos
Angle Closure Glaucoma: Treatment
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Tonsillitis II: Management
Impression Management Techniques I: Managing Appearances
Managing Impressions
Management of Insomnia

