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Related Experiment Video

Updated: Feb 1, 2026

Zebrafish Corneal Wound Healing: From Abrasion to Wound Closure Imaging Analysis
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Wound Closure and Management.

David M Krpata1

  • 1Comprehensive Hernia Center, Digestive Disease and Surgical Institute , Cleveland Clinic, Cleveland, Ohio.

Surgical Infections
|December 12, 2018
PubMed
Summary
This summary is machine-generated.

For low-risk surgical incisions, primary closure with subcuticular sutures is recommended. High-risk wounds may benefit from adjunctive therapies like irrigation or negative pressure incisional therapy, warranting further investigation.

Keywords:
fascial closureskin closurewound closurewound management

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Area of Science:

  • Surgical wound management
  • Incisional morbidity reduction
  • Wound closure techniques

Background:

  • Surgical incision management and closure decisions are guided by anticipated incisional morbidity.
  • Patient-specific factors and potential morbidity severity influence these choices.

Purpose of the Study:

  • To review current literature on strategies for closing surgical skin and fascia incisions.
  • To provide evidence-based recommendations for wound closure techniques.

Main Methods:

  • Comprehensive review of existing scientific literature on surgical wound closure.
  • Analysis of studies evaluating different closure techniques and adjunctive therapies.

Main Results:

  • Low-risk wounds: Primary closure with subcuticular sutures is advised; avoid adjunctive local measures.
  • High-risk wounds: Consider adjunctive therapies such as irrigation, topical antimicrobials, and negative pressure incisional therapy (NPIT).
  • Contaminated wounds: Surgeons should strongly consider primary closure.

Conclusions:

  • Adjuncts like wound irrigation, topical antimicrobials, and NPIT show potential benefits for certain wounds.
  • Further research is needed to fully understand the impact of these adjuncts on cost, patient experience, and antibiotic stewardship.