Perfluorochemicals as oxygen transport vehicles.
1Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115.
Perfluorochemical liquids (PFCs) are effective gas carriers for biological applications. Phospholipid emulsions show promise over Pluronic F68 due to reduced complement activation, offering advantages in medical treatments.
Area of Science:
- Biomedical Engineering
- Biochemistry
- Medical Science
Background:
- Perfluorochemical liquids (PFCs) exhibit high gas solubility, making them valuable for biological applications.
- PFCs require emulsification for intravenous use and organ perfusion, with particle size crucial for stability.
Purpose of the Study:
- To evaluate the suitability of PFC emulsions as gas carriers in biological systems.
- To compare the biocompatibility of different emulsifying agents for PFCs.
Main Methods:
- Investigating the gas solubility properties of PFCs.
- Assessing the stability and biocompatibility of PFC emulsions stabilized by Pluronic F68 and phospholipids.
- Monitoring complement activation and its effects on leukocytes and oxygen tension.
Main Results:
- PFCs demonstrate significant oxygen and carbon dioxide solubility.
- Phospholipid-stabilized PFC emulsions do not activate complement, unlike Pluronic F68 emulsions.
- Pluronic F68 emulsions can cause reversible complement activation, transient leukopenia, and decreased oxygen tension.
Conclusions:
- Phospholipid-stabilized PFC emulsions are advantageous due to their lack of complement activation.
- PFC emulsions are being researched for tumor therapy, cardiac ischemia, and cerebral ischemia treatment.
- Further research into PFC applications in medicine is anticipated.
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