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Updated: Feb 1, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Multiple arteriovenous malformations caused by RASA1 gene mutation presenting during pregnancy - a case report and
Sara Manzocchi Besson1, Nicole Jastrow Meyer2, Henri Bounameaux1
11 Division of Angiology and Hemostasis, University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Abstract:
Pregnancy can influence the development and progression of congenital arteriovenous malformations (AVM) and thus lead to life-threatening complications for the mother and fetus like high output cardiac failure and premature delivery. The simultaneous presence of a capillary malformation and AVM strongly suggests a RASA1 related disorder. Keywords: Arteriovenous malformations, capillary malformation-arteriovenous malformation, capillaries/abnormalities, port-wine stain, pregnancy, RASA1 protein.
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