Related Experiment Videos
Cyclic neutropenia: a clinical review
1Department of Medicine, University of Washington School of Medicine, Seattle 98195.
Blood Reviews
|September 1, 1988
Summary
Cyclic neutropenia is a rare blood disorder causing periodic low white blood cell counts. Research suggests it stems from faulty regulation of early blood-forming cells, impacting overall health.
Area of Science:
- Hematology
- Genetics
- Immunology
Background:
- Cyclic neutropenia is a benign hematologic disorder.
- Characterized by recurrent severe neutropenia every 21 days.
- Associated with cyclical variations in other blood cells and symptoms like fever and mouth ulcers.
Purpose of the Study:
- To investigate the underlying causes of cyclic neutropenia.
- To explore the pathophysiology of this hematologic disorder.
- To review current and potential therapeutic strategies.
Main Methods:
- Clinical studies in human patients.
- Investigations in Grey Collie dogs with similar conditions.
- Analysis of hematopoietic precursor cell regulation.
Main Results:
- Cyclic neutropenia is strongly suggested to result from dysregulation of early hematopoietic precursor cells.
- Inherited cases follow an autosomal dominant pattern; others arise spontaneously.
- Acquired cases in adults may link to large granular lymphocyte proliferation.
Conclusions:
- Cyclic neutropenia is linked to abnormal regulation of hematopoietic stem cells.
- Current therapies manage symptoms and infections, but don't alter blood count cycles in children.
- Hematopoietic growth factor research offers promising future treatments.