Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

82.9K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
82.9K
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

8.4K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
8.4K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

594
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
594
Protein Digestion01:02

Protein Digestion

111.0K
Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
111.0K
Types of Hormones02:13

Types of Hormones

83.6K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.6K
Hormonal Regulation01:40

Hormonal Regulation

48.1K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
48.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells.

eLife·2024
Same author

Commensal bacteria maintain a Qa-1<sup>b</sup>-restricted unconventional CD8<sup>+</sup> T population in gut epithelium.

eLife·2023
Same author

Commensal Bacteria Maintain a Qa-1 <sup>b</sup> -restricted Unconventional CD8 <sup>+</sup> T Population in Gut Epithelium.

bioRxiv : the preprint server for biology·2023
Same author

The Role of T Cells in Obesity-Associated Inflammation and Metabolic Disease.

Immune network·2022
Same journal

Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy.

eLife·2026
Same journal

Analysis of dendritic input currents during place field dynamics.

eLife·2026
Same journal

TopoMetry systematically learns and evaluates the latent geometry of single-cell data.

eLife·2026
Same journal

Navigating the path: Advice to physician-scientists on choosing a clinical specialty.

eLife·2026
Same journal

Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex.

eLife·2026
Same journal

The exquisite mechanics of a tsetse bite.

eLife·2026
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
06:50

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

Published on: December 29, 2014

12.4K

A peptide puzzle.

Jian Guan1, Nilabh Shastri1

  • 1Department of Pathology, Johns Hopkins School of Medicine, Baltimore, United States.

Elife
|December 12, 2018
PubMed
Summary
This summary is machine-generated.

Cancer can develop even when the immune system is capable of eliminating it. This research explores the complex reasons behind immune evasion in cancer development, offering new insights into tumor immunology.

Keywords:
cancer biologycancer immunologycancer immunotherapygenetic heterogeneitymousetumor antigenstumor evolutiontumor resistance to immune response

More Related Videos

Measuring Peptide Translocation into Large Unilamellar Vesicles
12:27

Measuring Peptide Translocation into Large Unilamellar Vesicles

Published on: January 27, 2012

14.2K
Measuring RAN Peptide Toxicity in C. elegans
10:49

Measuring RAN Peptide Toxicity in C. elegans

Published on: April 30, 2020

7.1K

Related Experiment Videos

Last Updated: Feb 1, 2026

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
06:50

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

Published on: December 29, 2014

12.4K
Measuring Peptide Translocation into Large Unilamellar Vesicles
12:27

Measuring Peptide Translocation into Large Unilamellar Vesicles

Published on: January 27, 2012

14.2K
Measuring RAN Peptide Toxicity in C. elegans
10:49

Measuring RAN Peptide Toxicity in C. elegans

Published on: April 30, 2020

7.1K

Area of Science:

  • Immunology
  • Oncology
  • Cancer Biology

Background:

  • The immune system plays a crucial role in identifying and eliminating cancerous cells.
  • Despite immune surveillance, cancer develops in many individuals, posing a significant clinical challenge.

Purpose of the Study:

  • To investigate the mechanisms by which cancer cells evade immune detection and destruction.
  • To understand why the immune system fails to eliminate nascent tumors in certain contexts.

Main Methods:

  • Analysis of immune cell interactions with tumor microenvironments.
  • Investigation of molecular pathways involved in immune evasion.
  • Comparative studies of immune-competent hosts with tumor development.

Main Results:

  • Identified specific immune evasion strategies employed by cancer cells.
  • Demonstrated that certain tumor microenvironments can suppress anti-tumor immune responses.
  • Highlighted the role of immune cell dysfunction in cancer progression.

Conclusions:

  • Cancer development despite a capable immune system is due to sophisticated immune evasion tactics.
  • Targeting immune evasion mechanisms presents a promising therapeutic avenue for cancer treatment.