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Pediatric forms of vasculitis

Seza Özen1, Hafize Emine Sönmez1, Selcan Demir1

  • 1Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Best Practice & Research. Clinical Rheumatology
|December 12, 2018
PubMed

Insights

Childhood vasculitides are complex disorders impacting multiple body systems. This review highlights key differences between pediatric and adult vasculitis, including monogenic forms like DADA2 and HA20.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Genetics

Background:

  • Childhood vasculitides are complex, potentially severe systemic inflammatory disorders.
  • Recent advances include classification criteria and outcome measures for pediatric vasculitis.
  • Significant differences exist between childhood and adult vasculitis presentations and management.

Purpose of the Study:

  • To review childhood vasculitides.
  • To emphasize distinctions between pediatric and adult vasculitis.
  • To discuss monogenic vasculitides like DADA2 and HA20.

Main Methods:

  • Literature review focusing on pediatric vasculitis.
  • Comparative analysis of childhood versus adult vasculitis.
  • Inclusion of monogenic forms of vasculitis.

Main Results:

  • Childhood vasculitides present unique challenges and affect various organ systems.
  • Advances in classification and assessment are improving pediatric care.
  • Monogenic forms like DADA2 and HA20 represent distinct etiological categories.

Conclusions:

  • Understanding pediatric vasculitis requires recognizing its unique features compared to adult forms.
  • Classification criteria and outcome assessments are crucial for managing childhood vasculitis.
  • Monogenic disorders are increasingly recognized as important causes of vasculitis in children.

Keywords:
Childhood vasculitidesClassificationManagementPrimary vasculitides

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