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Learning a complex dose-response relationship with the computer simulation CoaguSim.

Hesham Al-Sallami1, Swee-Kin Loke2

  • 1School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand.

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|December 12, 2018
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Summary
This summary is machine-generated.

A computer simulation improved pharmacy students' understanding of warfarin

Keywords:
CoagusimPharmacy educationSimulationWarfarin pharmacology

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Area of Science:

  • Pharmacology
  • Physiology
  • Medical Education

Background:

  • Coagulation is a complex physiological process.
  • Understanding anticoagulants like warfarin is challenging due to non-linear dynamics.
  • Computer simulations can aid in learning complex biological systems.

Purpose of the Study:

  • To implement and evaluate a computer simulation-enhanced workshop.
  • To assess the impact on student understanding of warfarin's time course.
  • To improve comprehension of anticoagulant pharmacokinetics and pharmacodynamics.

Main Methods:

  • Developed a coagulation simulation (CoaguSim).
  • Integrated CoaguSim into an undergraduate pharmacy therapeutics workshop.
  • Students used CoaguSim to test hypotheses based on a warfarin case study.

Main Results:

  • Significant improvement in MCQ scores from 45% to 81% post-workshop.
  • Students demonstrated enhanced understanding of warfarin's dose-response relationship.
  • Focus group interviews confirmed learning through hypothesis generation and testing.

Conclusions:

  • The computer simulation workshop effectively improved pharmacy students' grasp of warfarin.
  • Simulation-based learning enhances understanding of complex drug effects.
  • Further development of the simulation for other drugs is planned.