Student-directed interactive animation for learning cytochrome P450-mediated drug metabolism

In this study, we introduced a student self-directed interactive animation tool created to enhance student understanding of cytochrome P450 (CYP450) mediated drug metabolism.

The online learning tool was constructed in HTML5 computer code. It was implemented over four years in a second year pharmacy degree course where CYP450 metabolism was taught. Assessment was by comparing test scores of students using the learning tool with a previous class that did not and through survey data from the student users.

Use of the Cyber-CYP learning tool enhanced test performance on CYP450 metabolism-related questions in all years tested. Survey responses indicated that the learning tool was easy to use and facilitated student learning of CYP450-mediated drug metabolism.

This study has shown that complex and dynamic processes, such as CYP450 metabolism, can be more effectively communicated using student-centered, self-paced and interactive animations.