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Related Experiment Videos

Dexfenfluramine and feeding reward.

B G Hoebel1, L Hernandez, R C McClelland

  • 1Department of Psychology, Princeton University, New Jersey 08544.

Clinical Neuropharmacology
|January 1, 1988
PubMed
Summary

Dexfenfluramine, a serotonin-releasing agent, inhibits the lateral hypothalamic feeding-reward system. This compound selectively reduces self-stimulation, offering a targeted approach to appetite control.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Appetite Regulation

Background:

  • The lateral hypothalamic (LH) feeding-reward system is crucial for motivated feeding behaviors.
  • The mesolimbic dopamine system in the ventral tegmental area (VTA) is implicated in reward and self-administration.
  • Physiological signals like satiety and body weight modulate feeding-reward system activity.

Purpose of the Study:

  • To investigate the effects of dexfenfluramine on the LH feeding-reward system.
  • To differentiate the effects of dexfenfluramine from racemic fenfluramine on self-stimulation and stimulation-escape.
  • To explore the neurochemical mechanisms underlying dexfenfluramine's action.

Main Methods:

  • Review of background experiments and new findings.

Related Experiment Videos

  • Behavioral assays measuring self-stimulation and stimulation-escape.
  • Microdialysis to measure neurotransmitter release in the LH.

    • Main Results:

    • Dexfenfluramine selectively inhibited LH self-stimulation, unlike racemic fenfluramine which caused lethargy.
    • Dexfenfluramine did not affect stimulation-escape responses.
    • Microdialysis confirmed that dexfenfluramine releases serotonin in the LH.

    Conclusions:

    • Dexfenfluramine's inhibition of the feeding-reward system is mediated by serotonin release in the LH.
    • The d-isomer (dexfenfluramine) offers a more specific effect on feeding reward compared to racemic fenfluramine.
    • Serotonin release by dexfenfluramine may inhibit circuitry involved in feeding reward.