Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.8K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
Uncertainty in Measurement: Reading Instruments02:46

Uncertainty in Measurement: Reading Instruments

51.9K
Counting is the type of measurement that is free from uncertainty, provided the number of objects being counted does not change during the process. Such measurements result in exact numbers. By counting the eggs in a carton, for instance, one can determine exactly how many eggs are there in the carton. Similarly, the numbers of defined quantities are also exact. For example, 1 foot is exactly 12 inches, 1 inch is exactly 2.54 centimeters, and 1 gram is exactly 0.001 kilograms. Quantities...
51.9K
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

3.9K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.9K
Synthetic Biology02:55

Synthetic Biology

5.6K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.6K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.2K
Overview
80.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rational design of T-DNA vectors enables predictable, single-copy integration in <i>Arabidopsis thaliana</i>.

bioRxiv : the preprint server for biology·2026
Same author

Cryoneurolysis of auriculotemporal nerve for treatment of otalgia.

BMJ case reports·2026
Same author

In Memoriam: Robert M. Kelly (1953-2026).

Applied and environmental microbiology·2026
Same author

Epigenome regulators imbue a single eukaryotic promoter with diverse gene expression dynamics.

iScience·2026
Same author

In Memoriam: Robert M. Kelly (1953-2026).

Applied and environmental microbiology·2026
Same author

Reply to Comment on "Temporary Conjunctival Flap plus Medical Treatment versus Medical Treatment Only for High-Risk Fungal Keratitis: A Randomized Controlled Trial".

Cornea·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish
14:43

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish

Published on: July 18, 2020

8.6K

Engineering Epigenetic Regulation Using Synthetic Read-Write Modules.

Minhee Park1, Nikit Patel1, Albert J Keung2

  • 1Biological Design Center, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

Cell
|December 12, 2018
PubMed
Summary
This summary is machine-generated.

Scientists created a new epigenetic regulatory system in mammalian cells using N6-methyladenine (m6A) DNA modification. This system can program and maintain epigenetic memory, offering a novel toolkit for studying epigenetic regulation.

Keywords:
DNA methylationN6-methyladeninecell engineeringchromatinepigenetic memoryepigeneticsgene regulationread-writesynthetic biology

More Related Videos

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.9K
An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

7.0K

Related Experiment Videos

Last Updated: Feb 1, 2026

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish
14:43

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish

Published on: July 18, 2020

8.6K
In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.9K
An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

7.0K

Area of Science:

  • Epigenetics and Gene Regulation
  • Synthetic Biology
  • Mammalian Cell Biology

Background:

  • Chemical modifications to DNA and histones orchestrate epigenetic programs in cellular differentiation.
  • Regulatory networks of chromatin mark writers and readers control these epigenetic programs.

Purpose of the Study:

  • To establish an orthogonal epigenetic regulatory system in mammalian cells using N6-methyladenine (m6A).
  • To investigate the potential of synthetic "read-write" epigenetic architectures for programming cellular states.

Main Methods:

  • Development of synthetic factors to write and read m6A DNA modifications.
  • Construction of minimal regulatory circuits to induce and propagate m6A-dependent transcriptional states.
  • Utilizing mathematical modeling to understand epigenetic inheritance and chromatin spreading dynamics.

Main Results:

  • Successfully established a functional m6A-based epigenetic regulatory system in mammalian cells.
  • Demonstrated the ability of synthetic circuits to program de novo epigenetic functions.
  • Showcased spatial propagation and maintenance of epigenetic memory within induced transcriptional states.

Conclusions:

  • Conceptually validated "read-write" epigenetic architectures for programmable gene regulation.
  • Provided a novel toolkit for investigating epigenetic regulation models and encoding epigenetic information.
  • Highlighted the potential of synthetic epigenetics for advancing cell biology and synthetic biology.