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Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents
Published on: August 14, 2018
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Prematurity Does Not Increase Early Childhood Fracture Risk
Kari Wagner1, Scott Wagner2, Apryl Susi3
1Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD; Department of Pediatrics, Uniformed Services University, Bethesda, MD.
The Journal of Pediatrics
|December 12, 2018
Summary
Premature birth did not increase fracture risk by age 5. However, neonatal cholestasis and proton pump inhibitor use were linked to higher fracture rates in children.
Area of Science:
- Pediatrics
- Neonatology
- Orthopedics
Background:
- Prematurity is a significant concern in neonatal care.
- Understanding long-term health outcomes, including fracture risk, is crucial for preterm infants.
Purpose of the Study:
- To assess the association between prematurity and fracture risk up to age 5.
- To identify factors, including medications and comorbidities, that may influence fracture development in this cohort.
Main Methods:
- Retrospective cohort study of infants born between 2009-2010 with at least 5 years of follow-up.
- Fractures, comorbidities, and medication use (caffeine, diuretics, postnatal corticosteroids, antacids) identified via ICD-9 codes and pharmaceutical records.
- Poisson regression analysis used to determine fracture rates.
Main Results:
- No significant association was found between preterm birth at any gestational age and fracture rate by age 5.
- Increased fracture rates were observed in infants with cholestasis and those exposed to proton pump inhibitors.
- Male sex was also associated with a higher fracture rate.
Conclusions:
- Prematurity itself is not a risk factor for fractures by age 5.
- Neonatal cholestasis and proton pump inhibitor treatment are significant risk factors for fractures in early childhood.
- Further research into the mechanisms linking these conditions to bone health is warranted.
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