Related Experiment Video
Updated: Feb 1, 2026

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea
Published on: January 24, 2018
Does stromal interaction molecule-1 have five senses?
Peter B Stathopulos1, Mitsuhiko Ikura2
1Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, London, ON, N6A 5C1, Canada.
Abstract:
A single calcium (Ca2+) binding site within the canonical EF-hand loop was thought to govern the stromal interaction molecule-1 (STIM1) structural changes that lead to activation of Orai1 Ca2+ channels. Recent work by Gudlur et al., published in Nat Commun [9(1):4536], suggests that the STIM1 endoplasmic reticulum (ER) luminal domain has ∼5 additional Ca2+ binding sites, which underlie a surprising new proposal for Ca2+ sensing.
Related Concept Videos
The Sense of Self: Reflected Self-Appraisal and Social Comparison
Molecules and Compounds
Introduction to Special Senses
Predator-Prey Interactions
Tactile and Chemical Senses
piRNA - Piwi-interacting RNAs

