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Emerging roles of proteoglycans in cardiac remodeling

Xiaoya Wang1, Yi Lu1, Yao Xie1

  • 1Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Key Lab of Cardiovascular Disease of Zhejiang Province, Hangzhou, Zhejiang 310009, PR China.

International Journal of Cardiology
|December 12, 2018
PubMed

Insights

Proteoglycans, key extracellular matrix components, significantly modify cardiac remodeling in response to heart disease. Targeting proteoglycans offers potential therapeutic strategies for cardiovascular diseases.

Area of Science:

  • Cardiovascular Biology
  • Extracellular Matrix Research

Background:

  • Cardiac remodeling is the heart's adaptive response to pathological stimuli, which can lead to adverse clinical outcomes if sustained.
  • Hallmarks of cardiac remodeling include cardiomyocyte loss or hypertrophy, inflammation, and fibrosis.
  • Proteoglycans are extracellular matrix components crucial for cardiovascular development and function.

Purpose of the Study:

  • To investigate the role of proteoglycans in cardiac remodeling.
  • To explore the potential of proteoglycans as therapeutic targets for cardiovascular diseases.

Main Methods:

  • Review of existing literature on proteoglycans and cardiac remodeling.
  • Analysis of studies investigating proteoglycan function in models of cardiac stress (ischemia, pressure overload).

Main Results:

  • Proteoglycan deficiency leads to developmental cardiovascular defects.
  • Proteoglycans significantly modulate cardiac remodeling in response to ischemia and pressure overload.
  • Emerging evidence highlights proteoglycans' role in pathological cardiac remodeling.

Conclusions:

  • Proteoglycans are critical regulators of cardiac remodeling.
  • Modulating proteoglycan function presents a promising therapeutic avenue for cardiovascular diseases.
  • Further research into proteoglycans could improve cardiovascular disease prognosis.

Keywords:
Cardiac remodelingHeart failureMyocardial ischemiaPressure overloadProteoglycan

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