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Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview

Babatunde Fariyike1, Quante Singleton1, Monte Hunter1

  • 1Department of Orthopedics, Augusta University, Augusta, GA, United States.

Mechanisms of Ageing and Development
|December 12, 2018
PubMed

Insights

MicroRNAs regulate gene expression and are crucial for musculoskeletal health. MiRNA 141 is a focus for understanding its role in age-related musculoskeletal diseases like osteoarthritis and osteoporosis.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression by targeting messenger RNA (mRNA) 3' untranslated regions (UTRs).
  • miRNAs are vital for normal musculoskeletal functions, including stem cell differentiation, survival, apoptosis, osteogenesis, and chondrogenesis.
  • Dysregulation of miRNA expression is implicated in pathological conditions and age-related musculoskeletal decline, affecting stem cells, bone, and muscle tissues.

Purpose of the Study:

  • To review current literature on microRNA 141 (miRNA 141).
  • To explore the potential role of miRNA 141 in the pathogenesis of osteoporosis, osteoarthritis, and overall musculoskeletal pathology.

Main Methods:

  • Literature review of existing studies on miRNA 141.
  • Analysis of research linking miRNA expression to musculoskeletal diseases and aging.

Main Results:

  • Several miRNAs have been identified in osteoarthritis, osteoporosis, and sarcopenia.
  • MiRNA 141 is emerging as a molecule of interest due to its potential involvement in musculoskeletal pathology.

Conclusions:

  • Altered miRNA expression contributes to cellular dysfunction in degenerative musculoskeletal diseases.
  • MiRNA 141 warrants further investigation for its specific roles in osteoporosis, osteoarthritis, and age-related musculoskeletal degeneration.
Keywords:
MiR-200 familyMicroRNA-141agingmusculoskeletal

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