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Synthesis of zwitterionic N-chlorohydantoins for antibacterial applications
Lingdong Li1, Yanan Jin1, Hao Zhou2
1School of Petroleum and Chemical Engineering, Dalian University of Technology, State Key Laboratory of Fine Chemicals, 2 Dagong Road, Liaodongwan New District, Panjin 124221, China.
Abstract:
Two novel zwitterionic N-chlorohydantoin biocides, containing an N-chlorohydantoin unit and a sulfobetaine unit or a carboxybetaine unit, were chemically synthesized and characterized. Using the quaternary ammonium N-chlorohydantoin as control, the antibacterial activity of synthetic zwitterionic N-chlorohydantoins was challenged and the antibacterial data showed that carboxybetaine N-chlorohydantoin exhibited distinctively higher biocidal efficacy than QA counterpart, while sulfobetaine N-chlorohydantoin displayed slightly inferior antimicrobial efficacy. Our results may inspire further exploration of more zwitterionic N-chlorohydantoin analogs for antibacterial application.
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