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Updated: Feb 1, 2026

Electrophysiology of Scorpion Peg Sensilla
Published on: April 13, 2011
Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3
Claude Zoukimian1, Hervé Meudal2, Stephan De Waard3
1Department of Molecular Chemistry, Univ. Grenoble Alpes, CNRS, 570 rue de la chimie, CS 40700, Grenoble 38000, France; Smartox Biotechnology, 6 rue des platanes, Saint Egrève 38120, France.
Abstract:
The scorpion toxin AmmTx3 is a specific blocker of Kv4 channels. It was shown to have interesting potential for neurological disorders. In this study, we report the first chemical synthesis of AmmTx3 by using the native chemical ligation strategy and validate its biological activity. We determined its 3D structure by nuclear magnetic resonance spectroscopy, and pointed out that AmmTx3 possesses the well-known CSαβ structural motif, which is found in a large number of scorpion toxins. Overall, this study establishes an easy synthetic access to biologically active AmmTx3 toxin.
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