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Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

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Histopathologic and Clinical Correlation of Aberrant Neuromagnetic Activities with Low to High Frequency of Gliomas

Kun Yang¹, Jiu Chen², Jing Xiang³

¹Department of Neurosurgery, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

World Neurosurgery

|December 12, 2018

Abstract

Objective:

To quantify the low- to high-frequency range of abnormal brain activities and assess the histopathologic and clinical correlation in patients with glioma.

Methods:

Twenty-five patients with glioma and 20 healthy controls were examined with a magnetoencephalography (MEG) system. MEG data collected in 6 frequency bands, including 1-4 Hz, 4-8 Hz, 8-12 Hz, 12-30 Hz, 30-45 Hz, and 55-75 Hz, were analyzed by neuropathology to assess neuromagnetic signatures of glioma grade.

Results:

Compared with controls, patients with glioma showed greatly altered brain activities in 4-8 Hz, 8-12 Hz, and 55-75 Hz. Magnetic source power of brain activities in 4-8 Hz and 55-75 Hz in patients with high-grade gliomas significantly differed from that in patients with low-grade gliomas. The magnitude of source power of brain activities in 4-8 Hz and 55-75 Hz had marked correlation with the grading of gliomas in histopathological analyses.

Conclusions:

The degree of neuromagnetic source abnormality is a potential biomarker for noninvasive assessment of glioma grade. Because MEG tests can be performed noninvasively and preoperatively, MEG may play an important role in clinical biopsies and surgical planning for patients with brain gliomas in the future.

Keywords:

Accumulated source imaging Brain activities Glioma Magnetoencephalography Multiple frequency analysis

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