Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

849
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
849
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.7K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.7K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.7K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.7K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

818
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
818
Structure and Function of Platelets01:18

Structure and Function of Platelets

3.5K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.5K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

9.2K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Specific gut microbiome and metabolome changes in patients with continuous ambulatory peritoneal dialysis and comparison between patients with different dialysis vintages.

Frontiers in medicine·2024
Same author

Acta pharmaceutica Sinica. B·2024
Same author

Assessing psychometric properties and measurement invariance of the Sleep Quality Questionnaire among healthcare students.

BMC psychology·2024
Same author

Sema3A secreted by sensory nerve induces bone formation under mechanical loads.

International journal of oral science·2024
Same author

Sleep quality and subjective well-being in healthcare students: examining the role of anxiety and depression.

Frontiers in public health·2024
Same author

Exosomes Derived from hucMSCs Primed with IFN-γ Suppress the NF-κB Signal Pathway in LPS-Induced ALI by Modulating the miR-199b-5p/AFTPH Axis.

Cell biochemistry and biophysics·2024

Related Experiment Video

Updated: Feb 1, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K

Platelet for drug delivery.

Yifei Lu1, Quanyin Hu2, Chen Jiang1

  • 1Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.

Current Opinion in Biotechnology
|December 12, 2018
PubMed
Summary
This summary is machine-generated.

Platelets offer unique properties for drug delivery systems, enabling targeted therapies for wound healing and cancer. This review explores innovative strategies utilizing platelet functions for advanced therapeutic applications.

More Related Videos

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

10.0K
Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
05:53

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium

Published on: March 4, 2016

9.8K

Related Experiment Videos

Last Updated: Feb 1, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

10.0K
Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
05:53

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium

Published on: March 4, 2016

9.8K

Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Cell Biology

Background:

  • Platelets are crucial for hemostasis, inflammation, and tissue regeneration.
  • Platelet functions are increasingly explored for therapeutic applications, including drug delivery.
  • Their unique properties like rapid replenishment and site-specific targeting are advantageous.

Purpose of the Study:

  • To review current strategies for designing drug delivery systems that leverage platelet physiological functions.
  • To highlight innovative approaches in platelet-mediated drug delivery for various applications.
  • To provide an overview of advancements in the field of platelet-based therapeutics.

Main Methods:

  • Review of current literature on platelet-mediated drug delivery systems.
  • Categorization of strategies based on leveraging platelet functions.
  • Discussion of engineering, hitchhiking, membrane coating, synthetic fabrication, and triggered release methods.

Main Results:

  • Several strategies effectively utilize platelet properties for drug delivery.
  • Platelet engineering and synthetic fabrication offer novel avenues.
  • Platelet-triggered release mechanisms enhance therapeutic specificity.
  • These approaches show promise for wound healing and cancer treatment.

Conclusions:

  • Platelet-leveraging strategies represent a promising frontier in drug delivery.
  • Further research into platelet engineering and synthetic platelets is warranted.
  • These advanced systems hold potential for improved therapeutic outcomes in diverse medical conditions.