Aldehydes identified in commercially available ω-3 supplements via 1 H NMR spectroscopy

Cardiovascular disease (CVD) is the leading cause of mortality globally. Studies have suggested that supplementary ω-3 oils may provide cardiovascular protection, although the literature is equivocal. Recently, it has been established that many commercially available ω-3 supplements are unacceptably oxidized, leading to myriad potential health risks. One oxidation product of concern is aldehydes, which have been shown to have mutagenic, cytotoxic, and inflammatory properties that may contribute to many different disease processes, including CVD. The aim of this study was to assess the prevalence of aldehyde contamination in commercially available ω-3 supplements.

We tested 12 different ω-3 oils (6 fish, 4 krill, 2 algae), using 1 H-nuclear magnetic resonance scanning. This work is of a pilot nature, as such we randomly selected and purchased 12 different oils over the counter from various local retailers according to the sales representatives' recommendations.

The four krill products contained aldehydes at concentrations between 5.652 (±0.496) and 6.779 (±1.817) mMol/L. Both algae samples contained aldehydes: 1.235 (±0.111) and 1.565 (±0.618) mMol/L. Two of the six fish oils contained aldehydes 1.568 (±0.291) and 4.319 (±2.361) mMol/L. There is currently no standard for aldehyde content nor for labeling of ω-3 supplements. Two-thirds (8 of 12) of the ω-3 supplements tested in this study contained aldehydes. Aldehydes have the potential to precipitate serious health problems even at very low absolute intake volumes. These findings may provide reason for sober reflection.