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Related Experiment Video

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Covalent Attachment of Single Molecules for AFM-based Force Spectroscopy

Covalent Attachment of Single Molecules for AFM-based Force Spectroscopy

Published on: March 16, 2020

Dynamical modeling of manipulation process in Trolling-Mode AFM.

S Zahra Mohammadi¹, Majid Moghadam¹, Hossein Nejat Pishkenari²

¹Mechatronics laboratory, Department of Mechanical Engineering, Tarbiat Modares University, Tehran, Iran.

Ultramicroscopy

|December 12, 2018

Summary

This study presents a dynamical model for Trolling-mode Atomic Force Microscopy (AFM) in manipulating biological samples. The model accounts for hydrodynamic forces and nanoneedle deflection, enabling reliable simulation of nanoscale interactions in liquid.

Keywords:

Liquid environment Lumped model Manipulation Trolling-Mode AFM

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Area of Science:

Nanotechnology
Biophysics
Materials Science

Background:

Atomic Force Microscopy (AFM) is crucial for studying biological materials in liquid.
Operating in liquid degrades AFM sensitivity due to hydrodynamic drag.
A nanoneedle is needed to overcome liquid interference while transmitting forces.

Purpose of the Study:

To develop a dynamical lumped model for Trolling-mode AFM manipulation of bio-samples.
To account for nanoneedle deflection and hydrodynamic forces in liquid.
To simulate and analyze the critical conditions of nanoscale manipulation.

Main Methods:

Analytical and finite element stress analysis of nanoneedle and cantilever.
JKR theory for contact mechanics modeling.
Inclusion of drag and meniscus forces to simulate liquid media effects.
Numerical solution of governing equations using ODE45 for system simulation.

Main Results:

Simulation identified critical sliding conditions (time and force).
Illustrated changes in pushing force, needle deflection, and indentation depths.
Observed effects of velocity variations and tested different nanoneedle heights.
Validated simulation by comparing results with previous work, confirming reliability.

Conclusions:

The developed dynamical model accurately simulates Trolling-mode AFM manipulation in liquid.
The model accounts for key physical interactions, including hydrodynamic drag and nanoneedle bending.
This simulation provides a reliable tool for understanding and optimizing nanoscale manipulation of biological samples.