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Expression of Mac-2 binding protein in human carotid atheroma is associated with plaque instability and clinical

Hao Xie1, Liming Chen2, Hang Liu3

  • 1Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 12, 2018
PubMed
Abstract

Insights

Mac-2 binding protein (M2BP) is elevated in advanced carotid plaques and vulnerable regions, correlating with clinical symptoms. This suggests M2BP may indicate plaque destabilization and ischemic events.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biomarker Discovery

Background:

  • Mac-2 binding protein (M2BP) is a pro-inflammatory protein linked to atherosclerosis and patient prognosis in coronary artery disease.
  • Investigating M2BP expression in human carotid plaques is crucial for understanding its role in disease progression.

Purpose of the Study:

  • To examine the expression of M2BP in human carotid plaques.
  • To correlate M2BP expression with clinical symptoms and plaque composition.

Main Methods:

  • Recruited 51 patients undergoing carotid endarterectomy.
  • Assessed M2BP expression via plasma levels, mRNA, and immunohistochemical staining.

Main Results:

  • M2BP was primarily expressed by macrophages (CD68+) within plaques.
  • Elevated M2BP levels were found in advanced, ruptured plaques and vulnerable regions.
  • Higher M2BP expression correlated with symptomatic patients, plaque instability markers (echolucency, heterogeneity), and increased macrophage/apoptotic content.

Conclusions:

  • M2BP is highly expressed in advanced carotid plaques and vulnerable areas.
  • M2BP expression correlates significantly with clinical ischemic manifestations.
  • M2BP shows potential as a biomarker for plaque destabilization.
Keywords:
InflammationMac-2 binding proteinPlaque instability

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