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Ultratrace antibiotic sensing using aptamer/graphene-based field-effect transistors.

Xiaoyan Chen1, Ying Liu1, Xian Fang1

  • 1State Key Laboratory of Pollution Control and Resource Reuse, International Joint Research Center for Sustainable Urban Water System, College of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China.

Biosensors & Bioelectronics
|December 12, 2018
PubMed
Summary

This study introduces a novel electronic sensor for detecting antibiotic residue. The field-effect transistor (FET) based sensor offers rapid, sensitive, and specific detection of tobramycin, crucial for environmental and health monitoring.

Keywords:
AntibioticAptamerDebye lengthField-effect transistorMicrofluidic chip

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Area of Science:

  • Environmental Science
  • Analytical Chemistry
  • Materials Science

Background:

  • Antibiotic residue is a growing pollution concern impacting ecosystems and human health.
  • Conventional detection methods are complex and time-consuming, necessitating real-time, in situ monitoring solutions.

Purpose of the Study:

  • To develop a miniaturized, integratable electronic sensor for rapid and sensitive antibiotic detection.
  • To enhance sensor reliability and specificity for practical applications.

Main Methods:

  • Fabrication of a field-effect transistor (FET) sensor utilizing reduced graphene oxide (rGO) channel material.
  • Modification of rGO with tobramycin-specific aptamer RNA as the probe.
  • Implementation of a novel blocking layer (BL) using 6-mercapto-1-hexanol (MCH)/1-pyrenebutanol (PBA) for optimized sensor design.

Main Results:

  • The developed rGO/aptamer/BL sensor demonstrated ultra-sensitivity to tobramycin with a low detection limit of 0.3 nM.
  • Achieved rapid response time within 5 seconds and high specificity against other antibiotics.
  • Proposed a sensing mechanism involving aptamer probe deformation due to tobramycin interaction.

Conclusions:

  • The novel FET-based sensor provides a highly sensitive, specific, and rapid method for tobramycin detection.
  • The sensor design shows significant potential for practical applications in environmental monitoring and public health.
  • This technology advances in situ and real-time monitoring of antibiotic pollution.