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MiR-let-7e inhibits invasion and magration and regulates HMGB1 expression in papillary thyroid carcinoma

Chao Ding1, Huiming Yu2, Chenlei Shi1

  • 1Departments of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, PR China; State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 12, 2018
PubMed

Insights

MicroRNA let-7e acts as a tumor suppressor in papillary thyroid carcinoma (PTC) by inhibiting cell migration and invasion. It targets high mobility group box 1 (HMGB1), suggesting potential therapeutic applications for PTC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Papillary thyroid carcinoma (PTC) incidence is rising globally.
  • MicroRNAs (miRNAs) are implicated in various cancers, but miR-let-7e's role in PTC is unclear.

Purpose of the Study:

  • To investigate the function of miR-let-7e in papillary thyroid carcinoma.
  • To elucidate the relationship between miR-let-7e and high mobility group box 1 (HMGB1) in PTC progression.

Main Methods:

  • Overexpression of miR-let-7e and knockdown of HMGB1 in PTC cells.
  • Analysis of cell migration, invasion, and proliferation.
  • Direct targeting validation of HMGB1 3'-UTR by miR-let-7e.

Main Results:

  • Overexpressing miR-let-7e or reducing HMGB1 inhibited PTC cell migration and invasion.
  • miR-let-7e directly targets HMGB1, downregulating its expression.
  • Restoring HMGB1 expression reversed the anti-tumor effects of miR-let-7e.

Conclusions:

  • miR-let-7e functions as a tumor suppressor in papillary thyroid carcinoma, likely via HMGB1 downregulation.
  • miR-let-7e plays a significant role in PTC progression.
  • miR-let-7e represents a potential therapeutic target for papillary thyroid carcinoma treatment.
Keywords:
High mobility group box 1Papillary thyroid carcinomamiR-let-7emicroRNAs

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