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A test of dopamine hyper- and hyposensitivity in alcohol use
Heather E Soder1, Troy A Webber2, Marina A Bornovalova2
1Department of Psychology, University of South Florida, 4202 East Fowler Ave, PCD 4118G, Tampa, FL 33620, United States; Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1941 East Road, BBSB 1st Floor, Houston, TX 77054, United States.
Abstract:
Biases in outcome processing, mediated by the mesocortical dopaminergic (DA) system, may predict individual differences in the frequency and quantity of alcohol use. We tested the hypothesis that genetic markers associated with increased DA neurotransmission contribute to reduced neural sensitivity to costs and increased alcohol use in an undergraduate sample. We created a DA transmission score using five genetic markers related to DA transmission and assessed neural sensitivity to cost using the feedback-related negativity (FRN), an event-related potential implicated in neural outcome evaluation, on both passive evaluative and active decision-making tasks. Self-reported alcohol use was assessed using the Daily Drinking Questionnaire-Revised. Participants with a higher DA transmission score reported increased alcohol consumption and exhibited a more blunted FRN on both the passive and active tasks. While dopamine hyposensitivity is common among chronic alcohol users, these data provide preliminary evidence that hypersensitivity of the dopamine system may underlie increased alcohol use in those who have not yet developed a chronic alcohol use disorder.
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