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Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics
Published on: August 27, 2013
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Narrowband Shear Wave Generation Using Sinusoidally Modulated Acoustic Radiation Force.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
|December 12, 2018
Summary
Harmonic shear wave imaging (HSWI) generates controlled, narrowband shear waves using ultrasound. This new method closely matches magnetic resonance elastography (MRE) stiffness measurements, showing clinical potential.
Area of Science:
- Medical Imaging
- Biophysics
- Acoustics
Background:
- Transient ultrasound elastography (TUE) methods generate shear waves with broad frequency spectra, limiting control over wave energy distribution.
- This spectral characteristic can lead to discrepancies in shear-wave velocity measurements compared to harmonic methods like magnetic resonance elastography (MRE).
Purpose of the Study:
- To introduce a novel narrowband shear wave generation method using sinusoidally modulated ultrasound "push" pulses.
- To enable precise control over the main frequency of the excited shear waves.
Main Methods:
- Developed harmonic shear wave imaging (HSWI) by transmitting a series of push pulses with modulated intensity and duration.
- Interleaved push and imaging pulses using a single clinical transducer for both generation and recording.
- Compared HSWI with MRE and TUE using phantoms and in vivo measurements.
Main Results:
- HSWI successfully generated narrowband shear waves with a user-controlled main frequency.
- Shear wave speeds measured by HSWI closely matched those obtained by MRE.
- Acoustic output parameters of HSWI were found to be suitable for clinical applications.
Conclusions:
- HSWI offers a method for generating narrowband shear waves with a single linear array transducer, facilitating clinical translation.
- HSWI demonstrates potential for diagnosing soft tissue diseases by utilizing similar stiffness thresholds as MRE.
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