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Adiponectin, leptin and high sensitivity C-reactive protein values in obese children - important markers for

Ramona F Stroescu1,2, Otilia Mărginean1,2, Teofana Bizerea1,2

  • 1Louis Țurcanu Emergency Hospital for Children, Timișoara, Romania.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|December 12, 2018
PubMed

Insights

In obese children, adiponectin, leptin, and high-sensitivity C-reactive protein (hs-CRP) levels are significantly altered in those with metabolic syndrome (MetS). These adipokines can predict cardiovascular risk in this pediatric population.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Risk Assessment
  • Metabolic Disorders

Background:

  • Obesity is a chronic inflammatory condition.
  • Leptin, adiponectin, and C-reactive protein (CRP) are key players in obesity.
  • Understanding adipokine roles in pediatric metabolic syndrome is crucial.

Purpose of the Study:

  • Investigate relationships between adiposity markers (leptin, adiponectin, hs-CRP) and metabolic syndrome (MetS) in obese children.
  • Determine if these adipokines are significant markers for defining MetS in the pediatric population.

Main Methods:

  • A 1-year cross-sectional study involving 122 obese children.
  • Patients were grouped based on the presence or absence of MetS.
  • Analyzed adiponectin, leptin, and high-sensitivity C-reactive protein (hs-CRP) levels.

Main Results:

  • Metabolic syndrome (MetS) was identified in 27% of the obese children studied.
  • Adiponectin, leptin, and hs-CRP levels were significantly different in the MetS group (p=0.04, p=0.04, p=0.01).
  • No significant differences in age, sex, or BMI were observed between groups.

Conclusions:

  • High-sensitivity C-reactive protein (hs-CRP), leptin, and adiponectin show significant alterations in obese children with MetS.
  • These adipokines can serve as valuable predictors of cardiovascular risk in the pediatric population.
  • Further research can explore therapeutic targets based on these findings.

Keywords:
adiponectinhigh sensitivity C-reactive proteinleptinpediatric population

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