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Related Concept Videos

Peripheral Nervous System: Ganglia and Nerves01:24

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The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Overview of Regeneration and Repair01:19

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Spinal Nerves: Plexus II01:21

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The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
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The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
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Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration
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Peripheral nerve regeneration and intraneural revascularization.

Martial Caillaud1, Laurence Richard2, Jean-Michel Vallat2

  • 1University of Limoges, Myelin Maintenance and Peripheral Neuropathies, Faculties of Medicine and Pharmacy, Limoges, France.

Neural Regeneration Research
|December 12, 2018
PubMed
Summary

Peripheral nerve injuries lack effective treatments. This review highlights nerve regeneration, focusing on how blood vessel regrowth (revascularization) is crucial for healing damaged peripheral nerves.

Keywords:
Sunderland's classificationWallerian degenerationangiogenesiscompressioncrushglyceroltransectiontraumatic

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Vascular Biology

Background:

  • Peripheral nerve injuries are common and debilitating, with limited treatment options.
  • Understanding the mechanisms of nerve regeneration is critical for developing new therapies.
  • Intraneural vascularization's role in nerve repair remains poorly understood.

Purpose of the Study:

  • To review the pathophysiology of traumatic peripheral nerve injuries.
  • To summarize animal models used in nerve regeneration research.
  • To investigate the role of intraneural vascularization in peripheral nerve regeneration.

Main Methods:

  • Literature review of nerve injury and regeneration.
  • Analysis of pathophysiological features and animal models.
  • Histological examination of rat sciatic nerves following glycerol-induced injury.

Main Results:

  • Wallerian degeneration and nerve regrowth processes were described.
  • Experimental data and literature suggest revascularization is vital for nerve repair.
  • Intraneural vascularization appears to be a critical, yet understudied, factor in regeneration.

Conclusions:

  • Peripheral nerve regeneration is a complex process involving vascularization.
  • Further research into intraneural vascularization is necessary to improve treatment strategies.
  • Targeting revascularization could offer new therapeutic avenues for nerve injuries.