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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Primary Active Transport01:47

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In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
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The total amount of energy acquired by primary producers in an ecosystem is called gross primary production (GPP). However, of this energy, producers use some for metabolic processes, and some is lost as heat, decreasing the amount of energy available to the next trophic level. The remaining usable amount of energy is called the net primary productivity (NPP). In terrestrial ecosystems, NPP is driven by climate, while light penetration and nutrient availability drive NPP in aquatic ecosystems.
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Related Experiment Video

Updated: Feb 1, 2026

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
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[Primary immunodeficiencies and hematological malignancies].

Hirokazu Kanegane1, Akihiro Hoshino2, Masatoshi Takagi2

  • 1Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|December 12, 2018
PubMed
Summary

Primary immunodeficiency diseases (PIDs) impair the immune system, increasing risks for infections, autoimmune disorders, and malignancies. Germline mutations in PID genes can also cause cancers, especially hematopoietic malignancies.

Keywords:
Genetic predispositionHematopoietic malignancyPrimary immunodeficiency

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Area of Science:

  • Immunology
  • Oncology
  • Genetics

Background:

  • Primary immunodeficiency diseases (PIDs) are characterized by impaired immune function, leading to recurrent infections.
  • These conditions are frequently linked with autoimmune disorders and an elevated risk of malignancies.
  • Dysregulation of the adaptive immune system in PIDs contributes significantly to cancer susceptibility.

Purpose of the Study:

  • To elucidate the intricate relationship between primary immunodeficiency diseases and the development of malignancies.
  • To highlight the specific mechanisms underlying increased tumor susceptibility in PID patients.
  • To emphasize the association between PIDs and hematopoietic malignancies.

Main Methods:

  • Review of existing literature on PIDs and associated malignancies.
  • Analysis of immunological and genetic factors contributing to cancer risk in PID.
  • Focus on mechanisms such as defective tumor surveillance, apoptosis, and DNA repair.

Main Results:

  • Patients with PIDs exhibit heightened susceptibility to various cancers due to multiple immune defects.
  • Mechanisms include impaired cell-mediated surveillance, defective apoptosis, and altered responses to carcinogens and viruses.
  • Germline mutations in PID-related genes are a direct cause of certain malignancies, particularly in the hematopoietic system.

Conclusions:

  • There is a strong and complex association between primary immunodeficiency diseases and malignancies.
  • Understanding these links is crucial for managing PID patients and mitigating cancer risks.
  • Further research into PID-genotype correlations can improve cancer prevention and treatment strategies.