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[TP53 mutations and hematological malignancies]
Shinsuke Hirabayashi1, Suzuki Misato2, Atsushi Manabe1
1Department of Pediatrics, St. Luke's International Hospital.
Abstract:
TP53 is a tumor-suppressor gene, and it is the most commonly mutated somatic gene in human cancer. Germline TP53 mutations correlate with a hereditary predisposition to cancer. Comprehensive genetic analysis revealed the role of germline and somatic TP53 gene mutations in hematological malignancies. TP53 mutations affect the prognosis and therapeutic decision-making. Hence, genetic screening and tumor surveillance, including family members, should be performed when a germline TP53 mutation is detected in a patient.
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