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Updated: Feb 1, 2026

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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Periocular Manifestations of Afatinib Therapy

Varajini Joganathan1, Jonathan H Norris

  • 1Oxford University Hospital, Headley Way, Headington, Oxford, United Kingdom.

Ophthalmic Plastic and Reconstructive Surgery
|December 12, 2018
PubMed

Insights

Afatinib, an epidermal growth factor receptor tyrosine kinase inhibitor, can cause trichiasis, an eyelid condition. This rare side effect, observed in a spinal chordoma patient, highlights potential ocular complications of this cancer therapy.

Area of Science:

  • Oncology
  • Ophthalmology
  • Dermatology

Background:

  • Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are utilized for various cancers.
  • Afatinib is an EGFR-TKI used in cancer treatment.

Observation:

  • A 67-year-old female patient with spinal chordoma developed ocular symptoms after 6 months of Afatinib therapy.
  • Examination revealed trichomegaly, trichiasis, blepharitis, and corneal abrasion in all four eyelids, along with bilateral eyebrow hypertrichosis.

Findings:

  • Afatinib treatment was associated with the rare side effect of trichiasis and other ocular changes.
  • EGFR-TKI-induced hair changes result from epidermal growth factor receptor pathway activation in keratinocytes, leading to hair follicle remodeling.

Implications:

  • Clinicians should be aware of potential ocular side effects like trichiasis with Afatinib use.
  • Understanding the mechanism of EGFR-TKI-induced hair changes can help manage patient symptoms and treatment adherence.

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