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Acute High-Intensity Interval Exercise in Multiple Sclerosis with Mobility Disability.

Elizabeth A Hubbard1, Robert W Motl2, B O Fernhall3

  • 1Department of Kinesiology, Berry College, Mount Berry, GA.

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|December 12, 2018
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Summary
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High-intensity interval training (HIIT) significantly improves cardiorespiratory function in multiple sclerosis (MS) patients with mobility issues. This exercise approach taxes the system more than continuous training without adverse core temperature effects.

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Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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Area of Science:

  • Exercise Physiology
  • Neurological Rehabilitation
  • Clinical Exercise Science

Background:

  • Multiple sclerosis (MS) is a neurological disease causing progressive disability and physiological deconditioning.
  • High-intensity interval training (HIIT) shows promise for improving fitness in various populations.
  • The effectiveness and safety of HIIT for individuals with MS and mobility limitations are not well-established.

Purpose of the Study:

  • To compare the acute physiological and perceptual effects of HIIT versus continuous (CON) aerobic exercise using recumbent stepping in persons with MS and mobility disability.
  • To assess the feasibility and impact of different exercise intensities on physiological responses.

Main Methods:

  • Twenty individuals with MS (Expanded Disability Status Scale 4.0-6.5) participated in both HIIT and CON recumbent stepping sessions.
  • HIIT involved 10 cycles of 1-minute high-intensity intervals (90% peak aerobic capacity) followed by 1-minute recovery.
  • CON involved 20 minutes of continuous exercise at 50-60% peak aerobic capacity.

Main Results:

  • Significant condition-time interactions were observed for all physiological measures and perceived exertion, indicating different responses between HIIT and CON.
  • HIIT elicited significantly higher cardiorespiratory responses (oxygen consumption, ventilation, etc.) compared to CON.
  • No significant deleterious effects on core body temperature were noted with either exercise condition.

Conclusions:

  • HIIT significantly challenges the cardiorespiratory system more than CON exercise in individuals with MS and mobility disability.
  • These findings support HIIT as a potentially effective and safe exercise strategy for improving physiological conditioning in this population.
  • This research provides an evidence-based foundation for prescribing HIIT for persons with MS experiencing mobility challenges.